BAIT
A2M
A2MD, CPAMD5, FWP007, S863-7
alpha-2-macroglobulin
GO Process (10)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of complement activation, lectin pathway [IDA]
- negative regulation of endopeptidase activity [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NGF
Ngfb
nerve growth factor
GO Process (29)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- intracellular signal transduction [IDA]
- memory [ISO]
- negative regulation of neuron apoptotic process [IGI, ISO]
- negative regulation of type B pancreatic cell apoptotic process [ISO]
- nerve growth factor signaling pathway [IGI]
- neuron apoptotic process [IMP]
- neuron projection development [ISO]
- neuron projection morphogenesis [ISO]
- peripheral nervous system development [IMP]
- positive regulation of axon extension [IDA, IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of collateral sprouting [IDA]
- positive regulation of gene expression [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron maturation [IDA, IGI]
- positive regulation of neuron projection development [IDA, IGI]
- positive regulation of neurotrophin TRK receptor signaling pathway [ISO]
- positive regulation of protein autophosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stem cell proliferation [ISO]
- regulation of neuron differentiation [IDA]
- regulation of neurotransmitter secretion [IGI]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- sensory perception of pain [IMP, ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.
Methylamine-modified alpha-2-macroglobulin (MA-alpha 2M) has been recently shown to inhibit the biological activity of beta-nerve growth factor (NGF) in promoting neurite outgrowth by embryonic dorsal root ganglia in culture (Koo PH, Liebl DJ, J Neurosci Res 31:678-692, 1992). The objectives of this study are to determine whether alpha 2M can also be modified by larger aromatic biogenic amines such as ... [more]
J Neurosci Res Jun. 01, 1993; 35(2);170-82 [Pubmed: 7686585]
Throughput
- Low Throughput
Curated By
- BioGRID