A2M
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of complement activation, lectin pathway [IDA]
- negative regulation of endopeptidase activity [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NGF
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- intracellular signal transduction [IDA]
- memory [ISO]
- negative regulation of neuron apoptotic process [IGI, ISO]
- negative regulation of type B pancreatic cell apoptotic process [ISO]
- nerve growth factor signaling pathway [IGI]
- neuron apoptotic process [IMP]
- neuron projection development [ISO]
- neuron projection morphogenesis [ISO]
- peripheral nervous system development [IMP]
- positive regulation of axon extension [IDA, IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of collateral sprouting [IDA]
- positive regulation of gene expression [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron maturation [IDA, IGI]
- positive regulation of neuron projection development [IDA, IGI]
- positive regulation of neurotrophin TRK receptor signaling pathway [ISO]
- positive regulation of protein autophosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stem cell proliferation [ISO]
- regulation of neuron differentiation [IDA]
- regulation of neurotransmitter secretion [IGI]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- sensory perception of pain [IMP, ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.
Methylamine-modified alpha-2-macroglobulin (MA-alpha 2M) has been recently shown to inhibit the biological activity of beta-nerve growth factor (NGF) in promoting neurite outgrowth by embryonic dorsal root ganglia in culture (Koo PH, Liebl DJ, J Neurosci Res 31:678-692, 1992). The objectives of this study are to determine whether alpha 2M can also be modified by larger aromatic biogenic amines such as ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID