CYTH1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ARF6
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- cortical actin cytoskeleton organization [ISO]
- establishment of epithelial cell polarity [IMP]
- hepatocyte apoptotic process [IMP]
- liver development [IMP]
- myeloid cell apoptotic process [IMP]
- negative regulation of dendrite development [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- protein localization to cell surface [IDA]
- protein localization to endosome [IMP, ISO]
- protein transport [TAS]
- regulation of Rac protein signal transduction [ISO]
- regulation of dendritic spine development [IMP, ISO]
- regulation of filopodium assembly [ISO]
- regulation of toll-like receptor 4 signaling pathway [NAS]
- ruffle organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell cortex [ISO]
- cytoplasm [IDA]
- early endosome [ISO]
- endocytic vesicle [ISO]
- endosome [IDA, ISO, TAS]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- myelin sheath [IDA]
- plasma membrane [IDA, ISO]
- recycling endosome [ISO]
- recycling endosome membrane [ISO]
- ruffle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
The small GTPase ARL4C participates in the regulation of cell migration, cytoskeletal rearrangements, and vesicular trafficking in epithelial cells. The ARL4C signaling cascade starts by the recruitment of the ARF-GEF cytohesins to the plasma membrane, which, in turn, bind and activate the small GTPase ARF6. However, the role of ARL4C-cytohesin-ARF6 signaling during hippocampal development remains elusive. Here, we report that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARF6 CYTH1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.841 | BioGRID | 2679403 |
Curated By
- BioGRID