BAIT
CUL5
4921514I20Rik, 8430423K24Rik, AI852817, C030032G03Rik, C330021I08Rik, VACM-1, VACM1
cullin 5
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ARF6
AI788669, AW496366
ADP-ribosylation factor 6
GO Process (17)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- cortical actin cytoskeleton organization [ISO]
- establishment of epithelial cell polarity [IMP]
- hepatocyte apoptotic process [IMP]
- liver development [IMP]
- myeloid cell apoptotic process [IMP]
- negative regulation of dendrite development [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- protein localization to cell surface [IDA]
- protein localization to endosome [IMP, ISO]
- protein transport [TAS]
- regulation of Rac protein signal transduction [ISO]
- regulation of dendritic spine development [IMP, ISO]
- regulation of filopodium assembly [ISO]
- regulation of toll-like receptor 4 signaling pathway [NAS]
- ruffle organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell cortex [ISO]
- cytoplasm [IDA]
- early endosome [ISO]
- endocytic vesicle [ISO]
- endosome [IDA, ISO, TAS]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- myelin sheath [IDA]
- plasma membrane [IDA, ISO]
- recycling endosome [ISO]
- recycling endosome membrane [ISO]
- ruffle [ISO]
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis.
The small GTPase ARL4C participates in the regulation of cell migration, cytoskeletal rearrangements, and vesicular trafficking in epithelial cells. The ARL4C signaling cascade starts by the recruitment of the ARF-GEF cytohesins to the plasma membrane, which, in turn, bind and activate the small GTPase ARF6. However, the role of ARL4C-cytohesin-ARF6 signaling during hippocampal development remains elusive. Here, we report that ... [more]
Proc Natl Acad Sci U S A Dec. 15, 2019; 117(37);23073-23084 [Pubmed: 32873638]
Throughput
- Low Throughput
Curated By
- BioGRID