GHSR
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO, ISS]
- actin polymerization or depolymerization [ISO, ISS]
- adult feeding behavior [ISO, ISS]
- cellular response to insulin stimulus [ISO]
- decidualization [ISO, ISS]
- growth hormone secretion [ISO]
- hormone-mediated signaling pathway [ISO, ISS]
- negative regulation of inflammatory response [ISO, ISS]
- negative regulation of insulin secretion [IDA]
- negative regulation of interleukin-1 beta production [ISO, ISS]
- negative regulation of interleukin-6 biosynthetic process [ISO, ISS]
- negative regulation of tumor necrosis factor biosynthetic process [ISO, ISS]
- positive regulation of appetite [ISO, ISS]
- positive regulation of fatty acid metabolic process [IMP]
- positive regulation of insulin-like growth factor receptor signaling pathway [ISO]
- positive regulation of multicellular organism growth [ISO, ISS]
- regulation of hindgut contraction [IMP]
- regulation of synapse assembly [ISO]
- response to food [ISO]
- response to hormone [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SIGMAR1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors.
Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge eating, anorexia, bulimia) share a central control involving reward circuits. However, we here show that the sigma-1 receptor (?1R) mediates cocaine anorectic effects by interacting in neurons with growth/hormone/secretagogue (ghrelin) receptors. Cocaine increases colocalization of ?1R and GHS-R1a at the cell ... [more]
Throughput
- Low Throughput
Additional Notes
- PLA
Curated By
- BioGRID