PARP1
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [ISO]
- DNA metabolic process [IMP]
- DNA repair [TAS]
- base-excision repair [IMP]
- cellular response to insulin stimulus [ISO]
- cellular response to superoxide [IDA]
- double-strand break repair [IGI, ISO]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein ADP-ribosylation [IBA, ISO]
- protein autoprocessing [ISO]
- protein poly-ADP-ribosylation [ISO]
- regulation of growth rate [IMP]
- signal transduction involved in regulation of gene expression [ISO]
- telomere maintenance [IMP]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WWP2
Gene Ontology Biological Process
- negative regulation of gene expression [ISO]
- negative regulation of protein transport [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of transporter activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP, ISO]
- protein K63-linked ubiquitination [IMP]
- protein autoubiquitination [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane potential [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
The elevated expression of poly(ADP-ribose) polymerase-1 (PARP1) and increased PARP1 activity, namely, poly(ADP-ribosyl)ation (PARylation), have been observed in cardiac remodeling, leading to extreme energy consumption and myocardial damage. However, the mechanisms underlying the regulation of PARP1 require further study. WWP2, a HECT-type E3 ubiquitin ligase, is highly expressed in the heart, but its function there is largely unknown. Here, we ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID