JAK3
Gene Ontology Biological Process
- B cell differentiation [IBA, ISS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- STAT protein import into nucleus [TAS]
- T cell homeostasis [IBA, ISS, TAS]
- cell migration [IBA]
- enzyme linked receptor protein signaling pathway [ISS]
- erythrocyte differentiation [IBA]
- inflammatory response [IBA]
- innate immune response [IBA]
- interleukin-4-mediated signaling pathway [IDA]
- intracellular signal transduction [ISS]
- negative regulation of FasL biosynthetic process [ISS]
- negative regulation of T cell activation [ISS]
- negative regulation of T-helper 1 cell differentiation [ISS]
- negative regulation of dendritic cell cytokine production [ISS]
- negative regulation of interleukin-10 production [ISS]
- negative regulation of interleukin-12 production [ISS]
- negative regulation of thymocyte apoptotic process [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of T cell proliferation [IBA]
- protein phosphorylation [TAS]
- regulation of T cell apoptotic process [ISS]
- regulation of apoptotic process [IBA]
- response to interleukin-15 [TAS]
- response to interleukin-2 [TAS]
- response to interleukin-4 [IDA]
- response to interleukin-9 [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- tyrosine phosphorylation of STAT protein [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
JAK1
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [TAS]
- interleukin-2-mediated signaling pathway [IDA]
- peptidyl-tyrosine autophosphorylation [IBA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- response to antibiotic [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs.
PROTACs have recently emerged as a novel paradigm in drug discovery. They can hijack existing biological machinery to selectively degrade proteins of interest, in a catalytic fashion. Here we describe the design, optimisation and biological activity of a set of novel PROTACs targeting the Janus kinase family (JAK1, JAK2, JAK3 and TYK2) of proximal membrane-bound proteins. The JAK family proteins ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| JAK3 JAK1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID