STC1
Gene Ontology Biological Process
- bone development [IDA]
- cellular calcium ion homeostasis [IDA]
- chondrocyte proliferation [IDA]
- endothelial cell morphogenesis [IDA]
- growth plate cartilage axis specification [IDA]
- negative regulation of calcium ion transport [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of renal phosphate excretion [IDA]
- positive regulation of calcium ion import [IDA]
- regulation of anion transport [IDA]
- regulation of cardiac muscle cell contraction [IDA]
NOTCH1
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling involved in heart development [IMP]
- Notch signaling pathway [IMP, TAS]
- aortic valve morphogenesis [IMP]
- arterial endothelial cell differentiation [ISS]
- atrioventricular valve morphogenesis [ISS]
- cardiac atrium morphogenesis [ISS]
- cardiac chamber formation [ISS]
- cardiac epithelial to mesenchymal transition [ISS]
- cardiac left ventricle morphogenesis [ISS]
- cardiac muscle tissue morphogenesis [ISS]
- cardiac right atrium morphogenesis [ISS]
- cardiac septum morphogenesis [ISS]
- cardiac vascular smooth muscle cell development [ISS]
- cardiac ventricle morphogenesis [ISS]
- cell migration involved in endocardial cushion formation [ISS]
- cellular response to follicle-stimulating hormone stimulus [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- cilium morphogenesis [ISS]
- coronary artery morphogenesis [ISS]
- coronary vein morphogenesis [ISS]
- determination of left/right symmetry [ISS]
- endocardial cell differentiation [ISS]
- endocardial cushion morphogenesis [ISS]
- endocardium development [ISS]
- endocardium morphogenesis [ISS]
- epithelial to mesenchymal transition [ISS]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- gene expression [TAS]
- growth involved in heart morphogenesis [ISS]
- heart development [IMP]
- heart looping [ISS]
- heart trabecula morphogenesis [ISS]
- immune response [NAS]
- mesenchymal cell development [ISS]
- mitral valve formation [IMP]
- negative regulation of BMP signaling pathway [ISS]
- negative regulation of anoikis [IMP]
- negative regulation of catalytic activity [ISS]
- negative regulation of cell migration involved in sprouting angiogenesis [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of endothelial cell chemotaxis [IDA]
- negative regulation of glial cell proliferation [ISS]
- negative regulation of myoblast differentiation [IMP]
- negative regulation of myotube differentiation [ISS]
- negative regulation of neurogenesis [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of ossification [ISS]
- negative regulation of osteoblast differentiation [ISS]
- negative regulation of pro-B cell differentiation [ISS]
- negative regulation of stem cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- neuronal stem cell maintenance [IEP]
- pericardium morphogenesis [ISS]
- positive regulation of BMP signaling pathway [ISS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISS]
- positive regulation of transcription of Notch receptor target [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- pulmonary valve morphogenesis [IMP]
- regulation of extracellular matrix assembly [ISS]
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [ISS]
- regulation of transcription, DNA-templated [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- tube formation [IMP]
- vasculogenesis involved in coronary vascular morphogenesis [ISS]
- venous endothelial cell differentiation [ISS]
- ventricular septum morphogenesis [IMP]
- ventricular trabecula myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Stanniocalcin-1 augments stem-like traits of glioblastoma cells through binding and activating NOTCH1.
Glioblastoma (GBM) is a fatal tumor and comprises heterogeneous cells in which a subpopulation with stem cell-like properties is included. Cancer cells with stem cell-like properties account for tumor initiation, drug resistance and recurrence. To identify and characterize specific factors in regulating stem-like traits is critical for GBM therapeutic. Here, we showed that Stanniocalcin-1 (STC1), a secretory glycoprotein, functions as ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NOTCH1 STC1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| STC1 NOTCH1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID