CD151
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITGA3
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell-matrix adhesion [TAS]
- extracellular matrix organization [TAS]
- leukocyte migration [TAS]
- lung development [IMP]
- mesodermal cell differentiation [IEP]
- nephron development [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- regulation of BMP signaling pathway [IMP]
- regulation of Wnt signaling pathway [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- renal filtration [IMP]
- skin development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Knockdown of cathepsin B and uPAR inhibits CD151 and ?3?1 integrin-mediated cell adhesion and invasion in glioma.
Glioma is a highly complex brain tumor characterized by the dysregulation of proteins and genes that leads to tumor metastasis. Cathepsin B and uPAR are overexpressed in gliomas and they are postulated to play central roles in glioma metastasis. In this study, efficient downregulation of cathepsin B and uPAR by siRNA treatments significantly reduced glioma cell adhesion to laminin as ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD151 ITGA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9988 | BioGRID | 3154643 | |
| CD151 ITGA3 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID