PSF1
Gene Ontology Biological Process
Gene Ontology Cellular Component
POL32
Gene Ontology Biological Process
- DNA amplification [IMP]
- DNA replication, removal of RNA primer [IDA]
- RNA-dependent DNA replication [IDA]
- base-excision repair [TAS]
- double-strand break repair via break-induced replication [IMP]
- lagging strand elongation [TAS]
- leading strand elongation [TAS]
- mismatch repair [NAS]
- nucleotide-excision repair [TAS]
- postreplication repair [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Recombination and Pol ? Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ? Interaction.
The CMG complex (Cdc45, Mcm2-7, GINS (Psf1, 2, 3, and Sld5)) is crucial for both DNA replication initiation and fork progression. The CMG helicase interaction with the leading strand DNA polymerase epsilon (Pol ?) is essential for the preferential loading of Pol ? onto the leading strand, the stimulation of the polymerase, and the modulation of helicase activity. Here, we ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PSF1 POL32 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2734 | BioGRID | 365469 | |
| POL32 PSF1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2286 | BioGRID | 2052111 | |
| PSF1 POL32 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1975 | BioGRID | 1967335 | |
| PSF1 POL32 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2652831 |
Curated By
- BioGRID