BAIT
CRHR1
CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L
corticotropin releasing hormone receptor 1
GO Process (10)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- cellular response to corticotropin-releasing hormone stimulus [IDA]
- corticotropin secretion [ISS]
- female pregnancy [NAS]
- immune response [TAS]
- negative regulation of voltage-gated calcium channel activity [IDA]
- parturition [TAS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IMP]
- regulation of corticosterone secretion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARRB1
ARB1, ARR1
arrestin, beta 1
GO Process (22)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IMP]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- membrane organization [TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of interleukin-8 production [IDA]
- negative regulation of protein ubiquitination [IDA]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of GTPase activity [IMP]
- positive regulation of Rho protein signal transduction [IMP]
- positive regulation of histone H4 acetylation [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of receptor internalization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ubiquitination [IMP]
- stress fiber assembly [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- GTPase activator activity [IMP]
- angiotensin receptor binding [IPI]
- enzyme inhibitor activity [TAS]
- histone acetyltransferase activity [IDA]
- insulin-like growth factor receptor binding [IPI]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IMP]
- ubiquitin protein ligase binding [IPI]
- GTPase activator activity [IMP]
- angiotensin receptor binding [IPI]
- enzyme inhibitor activity [TAS]
- histone acetyltransferase activity [IDA]
- insulin-like growth factor receptor binding [IPI]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IMP]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases.
The corticotropin releasing factor (CRF) type 1alpha receptor, a member of the G protein-coupled receptor (GPCR) subfamily B, is involved in the aetiology of anxiety and depressive disorders. In the present study, we examined the internalization and trafficking of the CRF1alpha receptor in both human embryonic kidney (HEK)293 cells and primary cortical neurons. We found that CRF1alpha receptor activation leads ... [more]
J Neurochem Feb. 01, 2006; 96(4);934-49 [Pubmed: 16412099]
Throughput
- Low Throughput
Additional Notes
- bioluminescence resonance energy transfer
Curated By
- BioGRID