MAPK10
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
JUN
Gene Ontology Biological Process
- SMAD protein import into nucleus [ISO]
- SMAD protein signal transduction [ISO]
- aging [IEP]
- angiogenesis [IMP, ISO]
- axon regeneration [ISO]
- cellular process [ISO]
- cellular response to calcium ion [ISO]
- cellular response to potassium ion starvation [IMP]
- circadian rhythm [IEP]
- leading edge cell differentiation [ISO]
- learning [IMP]
- liver development [ISO]
- membrane depolarization [IDA]
- microglial cell activation [ISO]
- monocyte differentiation [ISO]
- negative regulation by host of viral transcription [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein autophosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- outflow tract morphogenesis [ISO]
- positive regulation by host of viral transcription [ISO]
- positive regulation of DNA replication [IMP]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of monocyte differentiation [IDA]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of cell cycle [ISO]
- regulation of transcription, DNA-templated [ISO]
- release of cytochrome c from mitochondria [IMP]
- response to cAMP [IEP]
- response to cytokine [IEP]
- response to drug [IEP, ISO]
- response to hydrogen peroxide [IEP]
- response to lipopolysaccharide [IEP]
- response to mechanical stimulus [IEP]
- response to muscle stretch [ISO]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to radiation [IDA]
- transcription from RNA polymerase II promoter [IMP, TAS]
- transcription, DNA-templated [IDA]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- HMG box domain binding [IPI]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- Rho GTPase activator activity [ISO]
- cAMP response element binding [ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IC, IPI, TAS]
- protein homodimerization activity [IDA, TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [ISO]
- HMG box domain binding [IPI]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- Rho GTPase activator activity [ISO]
- cAMP response element binding [ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IC, IPI, TAS]
- protein homodimerization activity [IDA, TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17.
During the development of the sympathetic nervous system, the p75 neurotrophin receptor (p75NTR) has a dual function: promoting survival together with TrkA in response to NGF, but inducing cell death upon binding pro or mature brain-derived neurotrophic factor (BDNF). Apoptotic signaling through p75NTR requires activation of the stress kinase, JNK. However, the receptor also undergoes regulated proteolysis, first by a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID