BAIT
LGALS9
HUAT, LGALS9A
lectin, galactoside-binding, soluble, 9
GO Process (2)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
STOML2
SLP-2, HSPC108
stomatin (EPB72)-like 2
GO Process (14)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell activation [ISS]
- T cell receptor signaling pathway [IMP]
- cellular calcium ion homeostasis [IMP]
- interleukin-2 production [ISS]
- lipid localization [ISS]
- mitochondrial ATP synthesis coupled proton transport [IMP]
- mitochondrial calcium ion transport [IMP]
- mitochondrial protein processing [ISS]
- mitochondrion organization [IMP]
- positive regulation of cardiolipin metabolic process [IMP]
- positive regulation of mitochondrial DNA replication [IMP]
- positive regulation of mitochondrial membrane potential [IMP]
- protein oligomerization [IDA]
- stress-induced mitochondrial fusion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.
AMPK is a central regulator of metabolism and autophagy. Here we show how lysosomal damage activates AMPK. This occurs via a hitherto unrecognized signal transduction system whereby cytoplasmic sentinel lectins detect membrane damage leading to ubiquitination responses. Absence of Galectin 9 (Gal9) or loss of its capacity to recognize lumenal glycans exposed during lysosomal membrane damage abrogate such ubiquitination responses. ... [more]
Mol Cell Dec. 05, 2019; 77(5);951-969.e9 [Pubmed: 31995728]
Throughput
- High Throughput
Curated By
- BioGRID