SWI4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DBF4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase.
Checkpoints maintain the order of cell cycle events during DNA damage or incomplete replication. How the checkpoint response is tailored to different phases of the cell cycle remains poorly understood. The S-phase checkpoint for example results in the slowing of replication, which in budding yeast occurs by Rad53-dependent inhibition of the initiation factors Sld3 and Dbf4. Despite this, we show ... [more]
Throughput
- Low Throughput
Additional Notes
- genetic complex
- we observe much greater firing of early origins in the swi4-t/sld3-A/dbf4-A strain compared to swi4-t alone
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DBF4 SWI4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1718 | BioGRID | 1967857 |
Curated By
- BioGRID