BAIT
ATXN3
AT3, ATX3, JOS, MJD, MJD1, SCA3, RP11-529H20.5
ataxin 3
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- cellular response to heat [ISS]
- cellular response to misfolded protein [ISS]
- intermediate filament cytoskeleton organization [IMP]
- microtubule cytoskeleton organization [IMP]
- misfolded or incompletely synthesized protein catabolic process [ISS]
- monoubiquitinated protein deubiquitination [ISS]
- nervous system development [TAS]
- nucleotide-excision repair [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- protein K48-linked deubiquitination [IDA]
- protein K63-linked deubiquitination [IDA]
- regulation of cell-substrate adhesion [IMP]
- synaptic transmission [TAS]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KPNA2
IPOA1, QIP2, RCH1, SRP1alpha
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
GO Process (4)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Divalproex sodium regulates ataxin-3 translocation likely by an importin ?1-dependent pathway.
Nuclear localization of ataxin-3 plays a fundamental role in seeding aggregation and the pathology of spinocerebellar ataxia type 3 (SCA3). However, very few compounds that are able to modulate the nuclear transport of ataxin-3 have been identified. In our previous study, we found that divalproex sodium (DVS) reduced heat shock-induced nuclear localization of ataxin-3. However, the mechanism of DVS in ... [more]
Neuroreport Dec. 07, 2018; 30(11);760-764 [Pubmed: 31107713]
Throughput
- Low Throughput
Additional Notes
- assayed using GST (glutathione S-transferase) pull-down experiments
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KPNA2 ATXN3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 2908349 |
Curated By
- BioGRID