BAIT
TRIM8
AA408830, BB006755, GERP, Rnf27
tripartite motif-containing 8
GO Process (10)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- innate immune response [IDA, ISO]
- negative regulation of viral entry into host cell [IDA]
- negative regulation of viral release from host cell [IDA, ISO]
- negative regulation of viral transcription [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- protein ubiquitination [NAS]
- stem cell maintenance [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
KIF2C
4930402F02Rik, ESTM5, Knsl6, MCAK, X83316, RP23-59L24.10-001
kinesin family member 2C
GO Process (6)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
The faithful inheritance of chromosomes is essential for the propagation of organisms. In eukaryotes, central to this process is the mitotic spindle. Recently, we have identified TRIM8 as a gene aberrantly expressed in gliomas whose expression reduces the clonogenic potential in the patients' glioma cells. TRIM8 encodes an E3 ubiquitin ligase involved in various pathological processes, including hypertrophy, antiviral defense, ... [more]
Cancer Lett Dec. 31, 2019; 473();98-106 [Pubmed: 31904480]
Throughput
- High Throughput
Curated By
- BioGRID