BAIT
KCNB1
DRK1, EIEE26, KV2.1, h-DRK1
potassium voltage-gated channel, Shab-related subfamily, member 1
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CACNA1C
CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS
calcium channel, voltage-dependent, L type, alpha 1C subunit
GO Process (11)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- axon guidance [TAS]
- calcium ion import [IBA]
- calcium ion transport into cytosol [TAS]
- calcium-mediated signaling using extracellular calcium source [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- energy reserve metabolic process [TAS]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [TAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.
The voltage-gated K+ channel Kv2.1 serves a major structural role in the soma and proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to endoplasmic reticulum (ER). Although Kv2.1 clustering at neuronal ER-PM junctions (EPJs) is tightly regulated and highly conserved, its function remains unclear. By identifying and evaluating proteins in close spatial proximity to Kv2.1-containing EPJs, we ... [more]
Elife Dec. 30, 2018; 8(); [Pubmed: 31663850]
Throughput
- Low Throughput
Additional Notes
- assayed using TIRF (total internal reflection fluorescence microscopy)
Curated By
- BioGRID