GRIN2B
Gene Ontology Biological Process
- action potential [IMP]
- associative learning [IMP]
- behavioral fear response [ISO]
- behavioral response to pain [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transmembrane transport [ISO]
- cation transport [ISO]
- cellular response to amino acid stimulus [IEP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to magnesium starvation [IEP]
- cellular response to manganese ion [IEP]
- cellular response to organic cyclic compound [IEP]
- cerebral cortex development [IEP]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- fear response [ISO]
- hippocampus development [IEP]
- in utero embryonic development [ISO]
- ion transmembrane transport [IDA]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [TAS]
- long-term memory [IEP]
- memory [IDA, ISO]
- multicellular organismal response to stress [IEP]
- positive regulation of cell death [IDA, IMP]
- positive regulation of glutamate secretion [IDA]
- positive regulation of synaptic transmission [IMP]
- receptor clustering [IDA]
- regulation of MAPK cascade [IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of postsynaptic membrane potential [ISO]
- regulation of protein kinase A signaling [ISO]
- regulation of synaptic plasticity [ISO]
- response to amine [IEP]
- response to amphetamine [IEP]
- response to calcium ion [IEP]
- response to carbohydrate [IEP]
- response to cocaine [IEP]
- response to cytokine [IEP]
- response to electrical stimulus [IEP]
- response to ethanol [IEP, ISO]
- response to fungicide [IEP]
- response to growth hormone [IEP]
- response to magnesium ion [IEP]
- response to manganese ion [IEP]
- response to mechanical stimulus [IEP]
- response to methylmercury [IEP]
- response to organic cyclic compound [IEP]
- response to other organism [IEP]
- response to toxic substance [IEP]
- rhythmic process [IDA]
- sensory organ development [ISO]
- startle response [ISO]
- suckling behavior [ISO]
- synaptic transmission [ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- D2 dopamine receptor binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, ISO]
- beta-catenin binding [IPI]
- calcium channel activity [ISO]
- cation channel activity [ISO]
- cell adhesion molecule binding [IPI]
- drug binding [IPI]
- extracellular-glutamate-gated ion channel activity [IDA]
- glycine binding [ISO]
- interleukin-1 receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- ionotropic glutamate receptor binding [IPI]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- receptor binding [IPI]
- zinc ion binding [IDA]
- D2 dopamine receptor binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, ISO]
- beta-catenin binding [IPI]
- calcium channel activity [ISO]
- cation channel activity [ISO]
- cell adhesion molecule binding [IPI]
- drug binding [IPI]
- extracellular-glutamate-gated ion channel activity [IDA]
- glycine binding [ISO]
- interleukin-1 receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- ionotropic glutamate receptor binding [IPI]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- receptor binding [IPI]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO]
- Z disc [IDA]
- cell surface [ISO]
- dendritic spine [IDA]
- membrane [ISO]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA, ISO]
- synapse [IDA, ISO, TAS]
- synaptic cleft [IDA]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
GRIN2A
Gene Ontology Biological Process
- action potential [IMP]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transmembrane transport [IDA]
- cation transport [IDA]
- cellular response to amino acid stimulus [IMP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to magnesium ion [IEP]
- cellular response to manganese ion [IEP]
- cellular response to zinc ion [IMP]
- cerebral cortex development [IEP]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- directional locomotion [ISO]
- dopamine metabolic process [ISO]
- hippocampus development [IEP]
- ion transmembrane transport [IMP, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO]
- locomotion [ISO]
- memory [IDA, ISO]
- negative regulation of protein catabolic process [ISO]
- neurogenesis [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- protein localization [ISO]
- protein tetramerization [IDA]
- regulation of excitatory postsynaptic membrane potential [IMP, ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of sensory perception of pain [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- response to amine [IEP]
- response to ammonium ion [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to carbohydrate [IEP]
- response to cocaine [IEP]
- response to drug [IEP, ISO]
- response to ethanol [IEP, ISO]
- response to fungicide [IEP]
- response to light stimulus [IEP]
- response to manganese ion [IEP]
- response to methylmercury [IEP]
- response to organic cyclic compound [IEP]
- response to other organism [IEP]
- response to wounding [ISO]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- serotonin metabolic process [ISO]
- sleep [ISO]
- spinal cord development [IEP]
- startle response [ISO]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [IBA]
- visual learning [ISO]
Gene Ontology Molecular Function- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO]
- cell surface [ISO]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- membrane [ISO]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA, ISO]
- synapse [ISO, TAS]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits.
N-methyl-(D)-aspartate (NMDA) receptors are heteromultimeric ion channels that contain an essential GluN1 subunit and two or more GluN2 (GluN2A-GluN2D) subunits. The biophysical properties and physiological roles of synaptic NMDA receptors are dependent on their subunit composition. In the basolateral amygdala (BLA), it has been suggested that the plasticity that underlies fear learning requires activation of heterodimeric receptors composed of GluN1/GluN2B ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIN2B GRIN2A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRIN2A GRIN2B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRIN2A GRIN2B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID