ANK3
Gene Ontology Biological Process
- Golgi to plasma membrane protein transport [ISO]
- axon guidance [ISO]
- axonogenesis [ISO]
- establishment of protein localization [ISO]
- maintenance of protein location in plasma membrane [ISO]
- membrane assembly [IGI, ISO]
- mitotic cytokinesis [ISO]
- neuromuscular junction development [IEP]
- neuronal action potential [ISO]
- plasma membrane organization [ISO]
- positive regulation of cation channel activity [IMP]
- positive regulation of cell communication by electrical coupling [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of homotypic cell-cell adhesion [IMP]
- positive regulation of membrane depolarization during cardiac muscle cell action potential [IMP]
- positive regulation of membrane potential [IMP]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of sodium ion transmembrane transporter activity [IMP]
- positive regulation of sodium ion transport [IMP]
- protein localization to plasma membrane [IGI, IMP, ISO]
- protein targeting to plasma membrane [ISO]
- regulation of potassium ion transport [IDA]
- synapse organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA]
- Z disc [IDA]
- axon [ISO]
- axon initial segment [IDA, ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cell [ISO]
- cell surface [IDA]
- costamere [TAS]
- dendrite [IDA]
- intercalated disc [IDA, ISO]
- intracellular [ISO]
- lateral plasma membrane [ISO]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA]
- node of Ranvier [IDA, ISO]
- paranode region of axon [ISO]
- plasma membrane [IDA]
- postsynaptic membrane [IDA]
- sarcolemma [IDA, ISO]
- sarcoplasmic reticulum [IDA]
- spectrin-associated cytoskeleton [IDA]
- synapse [ISO]
- tight junction [ISO]
ACTB
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- Tat protein binding [ISO]
- kinesin binding [ISO]
- nitric-oxide synthase binding [ISO]
- nucleosomal DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- Tat protein binding [ISO]
- kinesin binding [ISO]
- nitric-oxide synthase binding [ISO]
- nucleosomal DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- NuA4 histone acetyltransferase complex [ISO]
- axon [IDA]
- blood microparticle [ISO]
- cortical cytoskeleton [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytosol [ISO, TAS]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- myelin sheath [ISO]
- nuclear chromatin [ISO]
- postsynaptic density [IDA]
- protein complex [IDA, ISO]
- ribonucleoprotein complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Nonmuscle myosin II isoforms interact with sodium channel alpha subunits.
Sodium channels play pivotal roles in health and diseases due to their ability to control cellular excitability. The pore-forming ?-subunits (sodium channel alpha subunits) of the voltage-sensitive channels (i.e., Nav1.1-1.9) and the nonvoltage-dependent channel (i.e., Nax) share a common structural motif and selectivity for sodium ions. We hypothesized that the actin-based nonmuscle myosin II motor proteins, nonmuscle myosin heavy chain-IIA/myh9, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID