SCN9A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MYH9
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- actin cytoskeleton reorganization [ISS]
- actin filament-based movement [ISS]
- angiogenesis [ISS]
- blood vessel endothelial cell migration [ISS]
- membrane protein ectodomain proteolysis [ISS]
- monocyte differentiation [ISS]
- platelet formation [ISS]
- positive regulation of calcium ion transport into cytosol [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of phagocytosis [IMP]
- protein transport [ISS]
- regulation of cell shape [ISS]
- sodium ion transmembrane transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [ISS]
- actomyosin contractile ring [ISS]
- cell leading edge [ISS]
- cleavage furrow [ISS]
- cytoplasm [IDA, ISS]
- cytosol [ISS]
- endosome [IDA]
- integrin complex [ISS]
- lateral plasma membrane [IDA]
- nucleus [ISS]
- phagocytic vesicle [IDA]
- plasma membrane [ISS]
- protein complex [IDA, ISS]
- ruffle [ISS]
- stress fiber [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Nonmuscle myosin II isoforms interact with sodium channel alpha subunits.
Sodium channels play pivotal roles in health and diseases due to their ability to control cellular excitability. The pore-forming ?-subunits (sodium channel alpha subunits) of the voltage-sensitive channels (i.e., Nav1.1-1.9) and the nonvoltage-dependent channel (i.e., Nax) share a common structural motif and selectivity for sodium ions. We hypothesized that the actin-based nonmuscle myosin II motor proteins, nonmuscle myosin heavy chain-IIA/myh9, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MYH9 SCN9A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID