NCAM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NCAN
Gene Ontology Biological Process
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- cell adhesion [IBA]
- central nervous system development [IBA]
- chondroitin sulfate biosynthetic process [TAS]
- chondroitin sulfate catabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- dermatan sulfate biosynthetic process [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan metabolic process [TAS]
- skeletal system development [IBA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Perineuronal Net Protein Neurocan Inhibits NCAM/EphA3 Repellent Signaling in GABAergic Interneurons.
Perineuronal nets (PNNs) are implicated in closure of critical periods of synaptic plasticity in the brain, but the molecular mechanisms by which PNNs regulate synapse development are obscure. A receptor complex of NCAM and EphA3 mediates postnatal remodeling of inhibitory perisomatic synapses of GABAergic interneurons onto pyramidal cells in the mouse frontal cortex necessary for excitatory/inhibitory balance. Here it is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID