PARK7
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- cell proliferation [TAS]
- cellular response to hydrogen peroxide [IMP]
- cellular response to oxidative stress [IMP]
- cellular response to reactive oxygen species [IMP]
- dopamine uptake involved in synaptic transmission [IMP]
- hydrogen peroxide metabolic process [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- mitochondrion organization [IMP]
- negative regulation of cell death [IMP]
- oxidation-reduction process [IMP]
- positive regulation of oxidative phosphorylation uncoupler activity [IMP]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- positive regulation of reactive oxygen species biosynthetic process [IDA]
- protein stabilization [IMP]
- regulation of inflammatory response [IMP]
- response to hydrogen peroxide [IDA, IMP]
- synaptic transmission, dopaminergic [IMP]
Gene Ontology Molecular Function
ITPR3
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IDA]
- calcium ion transport into cytosol [IDA]
- cellular response to cAMP [ISO]
- inositol phosphate-mediated signaling [IDA, ISO]
- long-term synaptic potentiation [IMP]
- memory [IMP]
- positive regulation of cytosolic calcium ion concentration [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [ISO]
- response to calcium ion [ISO]
- sensory perception of bitter taste [IMP]
- sensory perception of sweet taste [IMP]
- sensory perception of umami taste [IMP]
Gene Ontology Molecular Function- calcium ion binding [ISO]
- inositol 1,3,4,5 tetrakisphosphate binding [ISO]
- inositol 1,4,5 trisphosphate binding [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO]
- inositol hexakisphosphate binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein binding [IPI]
- calcium ion binding [ISO]
- inositol 1,3,4,5 tetrakisphosphate binding [ISO]
- inositol 1,4,5 trisphosphate binding [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO]
- inositol hexakisphosphate binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- apical part of cell [ISO]
- brush border [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [IDA, ISO]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- myelin sheath [ISO]
- neuronal cell body [ISO]
- nuclear envelope [ISO]
- nuclear outer membrane [ISO]
- nucleolus [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- receptor complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1.
Loss-of-function mutations in DJ-1 are associated with autosomal recessive early onset Parkinson's disease (PD), yet the underlying pathogenic mechanism remains elusive. Here we demonstrate that DJ-1 localized to the mitochondria-associated membrane (MAM) both in vitro and in vivo. In fact, DJ-1 physically interacts with and is an essential component of the IP3R3-Grp75-VDAC1 complexes at MAM. Loss of DJ-1 disrupted the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID