KCNB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTK2
Gene Ontology Biological Process
- JNK cascade [ISO]
- MAPK cascade [ISO]
- angiogenesis [IMP]
- blood vessel development [IMP]
- cellular chloride ion homeostasis [ISO]
- cellular component movement [TAS]
- cellular response to transforming growth factor beta stimulus [IDA]
- central nervous system neuron axonogenesis [IMP]
- endothelial cell migration [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of nucleus localization [IDA]
- extracellular matrix organization [IMP]
- growth hormone receptor signaling pathway [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, TAS]
- microtubule cytoskeleton organization [IDA]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IBA, ISO]
- negative regulation of axonogenesis [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of organ growth [IGI]
- negative regulation of synapse assembly [IMP]
- neuron migration [IDA, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of phagocytosis [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synaptic transmission [ISO]
- positive regulation of vasodilation [ISO]
- protein autophosphorylation [IDA, IMP, ISO]
- regulation of cell adhesion [IBA]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cell proliferation [ISO]
- regulation of cell shape [ISO]
- regulation of osteoblast differentiation [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO]
- intercalated disc [ISO]
- lamellipodium [IDA]
- nuclear body [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
- stress fiber [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Formation of Kv2.1-FAK complex as a mechanism of FAK activation, cell polarization and enhanced motility.
Focal adhesion kinase (FAK) plays key roles in cell adhesion and migration. We now report that the delayed rectifier Kv2.1 potassium channel, through its LD-like motif in N-terminus, may interact with FAK and enhance phosphorylation of FAK(397) and FAK(576/577). Overlapping distribution of Kv2.1 and FAK was observed on soma and proximal dendrites of cortical neurons. FAK expression promotes a polarized ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTK2 KCNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID