BDNF
Gene Ontology Biological Process
- axon extension [IDA]
- axon guidance [IMP]
- axon target recognition [IMP]
- behavioral fear response [IMP]
- dendrite development [IMP]
- dendrite extension [IDA]
- fear response [IMP]
- feeding behavior [IMP]
- gamma-aminobutyric acid signaling pathway [IDA]
- glutamate secretion [IPI]
- inner ear development [IMP]
- learning [ISO]
- learning or memory [IMP]
- mechanoreceptor differentiation [IGI]
- mitochondrial electron transport, NADH to ubiquinone [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell death [IMP]
- negative regulation of neuroblast proliferation [IDA]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron death [ISO]
- negative regulation of striated muscle tissue development [ISO]
- negative regulation of synaptic transmission, GABAergic [IDA]
- nerve development [IMP]
- nervous system development [ISO]
- neuron projection extension [ISO]
- neuron recognition [IMP]
- positive regulation of glucocorticoid receptor signaling pathway [ISO]
- positive regulation of long-term neuronal synaptic plasticity [ISO]
- positive regulation of neuron differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA, IMP, ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of synapse assembly [ISO]
- regulation of axon extension [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of inhibitory postsynaptic membrane potential [IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of metabolic process [IMP]
- regulation of neuron apoptotic process [IDA]
- regulation of retinal cell programmed cell death [IDA]
- regulation of short-term neuronal synaptic plasticity [ISO]
- regulation of synaptic plasticity [IDA]
- response to drug [IMP]
- taste bud development [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- ureteric bud development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NTRK2
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- brain-derived neurotrophic factor receptor signaling pathway [IMP]
- central nervous system neuron development [ISS]
- cerebral cortex development [ISS]
- learning [ISS]
- negative regulation of neuron apoptotic process [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of MAPK cascade [ISS]
- positive regulation of axonogenesis [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- protein autophosphorylation [ISS]
- regulation of Rac GTPase activity [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Novel agonist monoclonal antibodies activate TrkB receptors and demonstrate potent neurotrophic activities.
Tyrosine kinase receptor B (TrkB) mediates neurotrophic effects of brain-derived neurotrophic factor (BDNF) to increase neuronal survival, differentiation, synaptic plasticity, and neurogenesis. The therapeutic potential of TrkB activation using BDNF has been demonstrated well in several preclinical models of CNS diseases, validating TrkB as a promising drug target. Therefore, we aimed to develop TrkB-specific receptor agonists by using a monoclonal ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID