RHOA
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [TAS]
- apical junction assembly [IMP]
- apolipoprotein A-I-mediated signaling pathway [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- cleavage furrow formation [IDA]
- negative chemotaxis [IMP]
- negative regulation of axonogenesis [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- ossification involved in bone maturation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB import into nucleus [NAS]
- positive regulation of axonogenesis [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of stress fiber assembly [IDA]
- regulation of axonogenesis [TAS]
- regulation of cell migration [IMP]
- regulation of osteoblast proliferation [ISS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- spindle assembly involved in mitosis [IMP]
- substantia nigra development [IEP]
- trabecula morphogenesis [ISS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLEKHG5
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- endothelial cell chemotaxis [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.
Rnd3 (RhoE) protein belongs to the unique branch of Rho family GTPases that has low intrinsic GTPase activity and consequently remains constitutively active [1], [2]. The current consensus is that Rnd1 and Rnd3 function as important antagonists of RhoA signaling primarily by activating the ubiquitous p190 RhoGAP [3], but not by inhibiting the ROCK family kinases.Rnd3 is abundant in mouse ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID