An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

Ostapcuk V, Mohn F, Carl SH, Basters A, Hess D, Iesmantavicius V, Lampersberger L, Flemr M, Pandey A, Thomae NH, Betschinger J, Buehler M

De novo mutations in ADNP, which encodes activity-dependent neuroprotective protein (ADNP), have recently been found to underlie Helsmoortel-Van der Aa syndrome, a complex neurological developmental disorder that also affects several other organ functions 1 . ADNP is a putative transcription factor that is essential for embryonic development 2 . However, its precise roles in transcriptional regulation and development are not ... [more]

Nature Dec. 01, 2017; 557(7707);739-743 [Pubmed: 29795351]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

CBX1

Gene Ontology Biological Process

Gene Ontology Molecular Function

enzyme binding [ISO]histone methyltransferase binding [ISO]identical protein binding [IPI]protein binding [IPI]protein homodimerization activity [IPI]

Gene Ontology Cellular Component

SCAI

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]transcription corepressor activity [IDA, ISO]

Gene Ontology Cellular Component

Affinity Capture-MS

Publication

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

Throughput

Curated By

enzyme binding [ISO]
histone methyltransferase binding [ISO]
identical protein binding [IPI]
protein binding [IPI]
protein homodimerization activity [IPI]

protein binding [IPI]
transcription corepressor activity [IDA, ISO]