BAIT

METTL21E

4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY

ACO2

Aco-2, Aco3, D10Wsu183e
aconitase 2, mitochondrial
GO Process (3)
GO Function (4)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.

Wang C, Zhang B, Ratliff AC, Arrington J, Chen J, Xiong Y, Yue F, Nie Y, Hu K, Jin W, Tao WA, Hrycyna CA, Sun X, Kuang S

Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]

FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]

Throughput

  • High Throughput

Curated By

  • BioGRID