BAIT
METTL21E
4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
CTTN
1110020L01Rik, Ems1
cortactin
GO Process (12)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- cell motility [ISO]
- dendritic spine maintenance [IGI]
- focal adhesion assembly [ISO]
- intracellular protein transport [ISO]
- lamellipodium organization [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IGI]
- neuron projection morphogenesis [ISO]
- positive regulation of actin filament polymerization [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of axon extension [ISO]
- substrate-dependent cell migration, cell extension [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [ISO]
- cell cortex [IDA]
- cell junction [ISO]
- coated pit [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- lamellipodium [IDA, ISO]
- mitotic spindle midzone [IDA]
- ruffle [IDA]
- voltage-gated potassium channel complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.
Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]
FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]
Throughput
- High Throughput
Curated By
- BioGRID