BAIT
METTL21E
4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
GPX1
AI195024, AL033363, CGPx, GPx-1, GSHPx-1, Gpx
glutathione peroxidase 1
GO Process (46)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- UV protection [ISO]
- angiogenesis involved in wound healing [IMP]
- apoptotic process [IMP]
- blood vessel endothelial cell migration [IMP]
- cell proliferation [IMP]
- cell redox homeostasis [ISO]
- endothelial cell development [IMP]
- fat cell differentiation [IMP]
- glutathione metabolic process [ISO]
- heart contraction [IMP, ISO]
- hydrogen peroxide catabolic process [IMP, ISO]
- interaction with symbiont [IGI]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- lipid metabolic process [IMP]
- myoblast proliferation [IMP]
- myotube differentiation [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of inflammatory response to antigenic stimulus [IGI]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- oxidation-reduction process [ISO]
- positive regulation of protein kinase B signaling [IMP]
- protein oxidation [IMP]
- regulation of gene expression, epigenetic [ISO]
- regulation of mammary gland epithelial cell proliferation [ISO]
- regulation of neuron apoptotic process [IMP]
- regulation of proteasomal protein catabolic process [ISO]
- response to gamma radiation [IGI]
- response to hydrogen peroxide [IMP, ISO]
- response to hydroperoxide [IMP]
- response to lipid hydroperoxide [ISO]
- response to oxidative stress [IGI, IMP]
- response to reactive oxygen species [IMP]
- response to selenium ion [ISO]
- response to symbiotic bacterium [IGI]
- response to toxic substance [IMP]
- response to wounding [IMP]
- response to xenobiotic stimulus [IMP]
- sensory perception of sound [IMP]
- skeletal muscle fiber development [IMP]
- skeletal muscle tissue regeneration [IMP]
- temperature homeostasis [IGI]
- triglyceride metabolic process [IMP]
- vasodilation [IMP]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.
Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]
FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]
Throughput
- High Throughput
Curated By
- BioGRID