BAIT
METTL21E
4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
MYO1C
C80397, MMIb, MYO1E, NMI, mm1beta, myr2, RP23-136K12.2
myosin IC
GO Process (9)
GO Function (8)
GO Component (15)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell migration by vascular endothelial growth factor signaling pathway [ISO]
- positive regulation of protein targeting to membrane [ISO]
- positive regulation of vascular endothelial growth factor signaling pathway [ISO]
- protein targeting [ISO]
- protein targeting to membrane [ISO]
- regulation of tight junction assembly [ISO]
- transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basal plasma membrane [ISO]
- brush border [IDA]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- lateral plasma membrane [ISO]
- membrane [ISO, TAS]
- membrane raft [ISO]
- microvillus [ISO]
- mitochondrion [ISO]
- myosin I complex [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- stereocilium [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.
Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]
FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]
Throughput
- High Throughput
Curated By
- BioGRID