BAIT
METTL21E
4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
NME2
NM23-H2, NM23B, nm23-M2, RP23-378I13.2
NME/NM23 nucleoside diphosphate kinase 2
GO Process (19)
GO Function (7)
GO Component (12)
Gene Ontology Biological Process
- CTP biosynthetic process [ISO]
- GTP biosynthetic process [ISO]
- UTP biosynthetic process [ISO]
- integrin-mediated signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of myeloid leukocyte differentiation [ISO]
- nucleoside diphosphate phosphorylation [IBA, ISO]
- nucleoside triphosphate biosynthetic process [IBA, ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of keratinocyte differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein autophosphorylation [ISO]
- protein oligomerization [ISO]
- purine nucleotide metabolic process [IBA]
- pyrimidine nucleotide metabolic process [IBA]
- regulation of apoptotic process [IBA]
- regulation of epidermis development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.
Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]
FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]
Throughput
- High Throughput
Curated By
- BioGRID