BAIT
METTL21E
4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
RPS6
S6R
ribosomal protein S6
GO Process (16)
GO Function (4)
GO Component (13)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- T cell differentiation in thymus [IGI, IMP]
- T cell proliferation involved in immune response [IGI, IMP]
- TOR signaling [ISO]
- activation-induced cell death of T cells [IMP]
- erythrocyte development [IMP]
- gastrulation [IGI, IMP]
- glucose homeostasis [IDA]
- mitotic cell cycle checkpoint [IMP]
- mitotic nuclear division [IMP]
- negative regulation of apoptotic process [IMP]
- oogenesis stage [IMP]
- placenta development [IMP]
- positive regulation of apoptotic process [ISO]
- rRNA processing [IMP, ISO]
- ribosomal small subunit biogenesis [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell body [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytosolic small ribosomal subunit [IBA, IDA, ISO]
- dendrite [IDA, ISO]
- membrane [ISO]
- nucleolus [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- polysome [IDA]
- ribonucleoprotein complex [ISO]
- ribosome [IDA]
- small ribosomal subunit [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.
Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]
FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]
Throughput
- High Throughput
Curated By
- BioGRID