BAIT
METTL21E
4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
IQGAP1
AA682088, D7Ertd237e, D7Ertd257e, mKIAA0051
IQ motif containing GTPase activating protein 1
GO Process (12)
GO Function (9)
GO Component (21)
Gene Ontology Biological Process
- cellular response to calcium ion [ISO]
- cellular response to epidermal growth factor stimulus [IMP, ISO]
- cellular response to fibroblast growth factor stimulus [IMP]
- cellular response to platelet-derived growth factor stimulus [IMP]
- epidermal growth factor receptor signaling pathway [IMP, ISO]
- fibroblast growth factor receptor signaling pathway [IMP]
- negative regulation of dephosphorylation [IGI]
- neuron projection extension [ISO]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive regulation of protein kinase activity [IMP, ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- regulation of cytokine production [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [ISO]
- axon [ISO]
- cell junction [ISO]
- cell leading edge [IGI]
- cell-cell junction [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- lateral plasma membrane [IDA]
- membrane [IDA]
- microtubule [ISO]
- microtubule cytoskeleton [ISO]
- midbody [ISO]
- neuron projection [IGI, ISO]
- nucleoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [IDA, IGI]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.
Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]
FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]
Throughput
- High Throughput
Curated By
- BioGRID