BAIT
METTL21E
4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
VAPA
33kDa, VAP33
vesicle-associated membrane protein, associated protein A
GO Process (10)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- COPII-coated vesicle budding [ISO]
- ER to Golgi vesicle-mediated transport [ISO]
- cell death [ISO]
- negative regulation by host of viral genome replication [ISO]
- neuron projection development [ISO]
- positive regulation by host of viral genome replication [ISO]
- positive regulation by host of viral release from host cell [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- protein localization to endoplasmic reticulum [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.
Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]
FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]
Throughput
- High Throughput
Curated By
- BioGRID