BAIT
METTL21E
4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
ACTR3
1200003A09Rik, Arp3
ARP3 actin-related protein 3
GO Process (14)
GO Function (3)
GO Component (14)
Gene Ontology Biological Process
- Arp2/3 complex-mediated actin nucleation [ISO]
- asymmetric cell division [IGI]
- cilium morphogenesis [ISO]
- establishment or maintenance of cell polarity [IGI]
- meiotic cell cycle [IGI]
- meiotic chromosome movement towards spindle pole [IGI]
- meiotic cytokinesis [IGI]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of filopodium assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neuron differentiation [ISO]
- regulation of myosin II filament organization [ISO]
- spindle localization [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.
Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]
FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]
Throughput
- High Throughput
Curated By
- BioGRID