BAIT
METTL21E
4832428D23Rik, Gm991
methyltransferase like 21E
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
CAMK2D
2810011D23Rik, 8030469K03Rik, CaMK II, [d]-CaMKII
calcium/calmodulin-dependent protein kinase II, delta
GO Process (30)
GO Function (9)
GO Component (14)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- calcium ion transport [IDA, IMP]
- cardiac muscle cell contraction [ISO, ISS]
- cardiac muscle contraction [IDA]
- cell growth involved in cardiac muscle cell development [ISO]
- cellular potassium ion homeostasis [ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- negative regulation of sodium ion transmembrane transport [ISO]
- negative regulation of sodium ion transmembrane transporter activity [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of Rac protein signal transduction [ISO]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein autophosphorylation [IMP, ISO]
- protein oligomerization [ISO]
- protein phosphorylation [ISO]
- regulation of G2/M transition of mitotic cell cycle [ISO]
- regulation of cardiac muscle cell action potential [ISO]
- regulation of cell communication by electrical coupling [ISO]
- regulation of cellular localization [ISO]
- regulation of generation of L-type calcium current [ISO]
- regulation of membrane depolarization [ISO]
- regulation of relaxation of cardiac muscle [IGI, ISO]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- regulation of sodium ion transport [IDA]
- relaxation of cardiac muscle [ISO, ISS]
- response to hypoxia [ISO]
Gene Ontology Molecular Function- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [ISO, ISS]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [ISO, ISS]
- ion channel binding [IPI, ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
Gene Ontology Cellular Component
- T-tubule [IDA]
- axon initial segment [IDA]
- calcium channel complex [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- intercalated disc [IDA]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuronal cell body [IDA]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
- sarcoplasmic reticulum [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.
Skeletal muscles contain heterogeneous myofibers that are different in size and contractile speed, with type IIb myofiber being the largest and fastest. Here, we identify methyltransferase-like 21e (Mettl21e), a member of newly classified nonhistone methyltransferases, as a gene enriched in type IIb myofibers. The expression of Mettl21e was strikingly up-regulated in hypertrophic muscles and during myogenic differentiation in vitro and ... [more]
FASEB J Dec. 01, 2018; 33(8);9672-9684 [Pubmed: 31162944]
Throughput
- High Throughput
Curated By
- BioGRID