BAIT
HTT
HD, IT15
huntingtin
GO Process (8)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- Golgi organization [IMP]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- organ development [IBA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of protein phosphatase type 2A activity [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [IMP]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
OPA1
1200011N24Rik, AI225888, AI847218, lilr3, mKIAA0567
optic atrophy 1
GO Process (14)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- cellular senescence [ISO]
- inner mitochondrial membrane organization [ISO]
- mitochondrial fusion [IDA, ISO]
- mitochondrial genome maintenance [ISO]
- mitochondrion organization [IDA, ISO, NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of release of cytochrome c from mitochondria [IMP, ISO]
- neural tube closure [IMP]
- positive regulation of dendrite development [ISO]
- positive regulation of mitochondrial fusion [ISO]
- positive regulation of neuron maturation [ISO]
- visual perception [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.
The cascade of events that lead to cognitive decline, motor deficits, and psychiatric symptoms in patients with Huntington disease (HD) is triggered by a polyglutamine expansion in the N-terminal region of the huntingtin (HTT) protein. A significant mechanism in HD is the generation of mutant HTT fragments, which are generally more toxic than the full-length HTT. The protein fragments observed ... [more]
J Biol Chem Jul. 31, 2015; 290(31);19287-306 [Pubmed: 26025364]
Throughput
- Low Throughput
Curated By
- BioGRID