BAIT
HTT
HD, IT15
huntingtin
GO Process (8)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- Golgi organization [IMP]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- organ development [IBA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of protein phosphatase type 2A activity [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [IMP]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TGM2
G[a]h, TG2, TGase2, tTG, tTGas, RP23-396G1.2
transglutaminase 2, C polypeptide
GO Process (17)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- apoptotic cell clearance [ISO]
- blood vessel remodeling [ISO]
- branching involved in salivary gland morphogenesis [IMP]
- isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine [ISO]
- negative regulation of endoplasmic reticulum calcium ion concentration [IMP, ISO]
- peptide cross-linking [TAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell adhesion [IMP]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of mitochondrial calcium ion concentration [IMP, ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein homooligomerization [ISO]
- salivary gland cavitation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.
The cascade of events that lead to cognitive decline, motor deficits, and psychiatric symptoms in patients with Huntington disease (HD) is triggered by a polyglutamine expansion in the N-terminal region of the huntingtin (HTT) protein. A significant mechanism in HD is the generation of mutant HTT fragments, which are generally more toxic than the full-length HTT. The protein fragments observed ... [more]
J Biol Chem Jul. 31, 2015; 290(31);19287-306 [Pubmed: 26025364]
Throughput
- Low Throughput
Curated By
- BioGRID