BAIT
IFI16
IFNGIP1, PYHIN2
interferon, gamma-inducible protein 16
GO Process (24)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity [IMP]
- activation of innate immune response [IDA]
- cell proliferation [NAS]
- cellular response to glucose starvation [IDA]
- cellular response to ionizing radiation [IDA]
- defense response to virus [IMP]
- hemopoiesis [NAS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- monocyte differentiation [IDA]
- myeloid cell differentiation [NAS]
- negative regulation of DNA binding [IDA]
- negative regulation of cysteine-type endopeptidase activity [IDA]
- negative regulation of innate immune response [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of cytokine production [TAS]
- positive regulation of interleukin-1 beta production [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of type I interferon production [TAS]
- regulation of autophagy [IEP]
- regulation of gene expression, epigenetic [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter binding [IDA]
- double-stranded DNA binding [IDA]
- identical protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- transcription factor binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter binding [IDA]
- double-stranded DNA binding [IDA]
- identical protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- transcription factor binding [IDA]
Homo sapiens
PREY
FLNA
ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD, XX-FW83128A1.1
filamin A, alpha
GO Process (19)
GO Function (12)
GO Component (10)
Gene Ontology Biological Process
- actin crosslink formation [IDA]
- actin cytoskeleton reorganization [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IMP]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cilium assembly [IMP]
- cytoplasmic sequestering of protein [IMP]
- establishment of protein localization [IDA]
- negative regulation of protein catabolic process [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of transcription factor import into nucleus [IMP]
- protein localization to cell surface [IDA]
- protein stabilization [IMP]
- receptor clustering [IDA]
- spindle assembly involved in mitosis [IDA]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.
?-interferon-inducible protein-16 (IFI16), a key DNA sensor, triggers downstream STING-dependent type I interferon (IFN-I) production and antiviral immunity. However, it is still unclear how to negatively regulate IFI16 to avoid excessive IFN-I production and autoimmunity. Here, we find that STING directly interacts with IFI16 and facilitates IFI16 degradation via the ubiquitin-proteasome pathway by recruiting the E3 ligase TRIM21. The 1-pyrin ... [more]
Cell Rep Dec. 29, 2018; 29(5);1249-1260.e4 [Pubmed: 31665637]
Throughput
- High Throughput
Curated By
- BioGRID