BAIT

IFI16

IFNGIP1, PYHIN2
interferon, gamma-inducible protein 16
GO Process (24)
GO Function (8)
GO Component (7)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

Li D, Wu R, Guo W, Xie L, Qiao Z, Chen S, Zhu J, Huang C, Huang J, Chen B, Qin Y, Xu F, Ma F

?-interferon-inducible protein-16 (IFI16), a key DNA sensor, triggers downstream STING-dependent type I interferon (IFN-I) production and antiviral immunity. However, it is still unclear how to negatively regulate IFI16 to avoid excessive IFN-I production and autoimmunity. Here, we find that STING directly interacts with IFI16 and facilitates IFI16 degradation via the ubiquitin-proteasome pathway by recruiting the E3 ligase TRIM21. The 1-pyrin ... [more]

Cell Rep Dec. 29, 2018; 29(5);1249-1260.e4 [Pubmed: 31665637]

Throughput

  • High Throughput

Curated By

  • BioGRID