BAIT
SOX17
SRY (sex determining region Y)-box 17
GO Process (52)
GO Function (11)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [IGI]
- canonical Wnt signaling pathway [IDA]
- cardiac cell fate determination [ISO]
- cardiogenic plate morphogenesis [IMP]
- cell migration involved in gastrulation [IMP]
- common bile duct development [IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic heart tube development [IGI]
- embryonic heart tube morphogenesis [IMP]
- embryonic organ development [IMP]
- endocardial cell differentiation [IGI]
- endocardium formation [IGI]
- endoderm development [IMP]
- endoderm formation [ISO]
- endodermal cell fate determination [IDA]
- endodermal digestive tract morphogenesis [IMP]
- gall bladder development [IMP]
- gastrulation [IMP]
- heart looping [IMP]
- inner cell mass cellular morphogenesis [IMP]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of Wnt signaling pathway [IDA, IMP]
- negative regulation of Wnt signaling pathway involved in heart development [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of mesodermal cell fate specification [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- outflow tract morphogenesis [IGI]
- positive regulation of cell differentiation [IDA, IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein catabolic process [IDA]
- positive regulation of skeletal muscle tissue development [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein destabilization [ISO]
- protein stabilization [ISO]
- regulation of cardiac cell fate specification [IMP]
- regulation of cell differentiation [IMP]
- regulation of embryonic development [IMP]
- regulation of mesodermal cell fate specification [IMP]
- regulation of stem cell division [IMP]
- regulation of stem cell proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification [IMP]
- regulation of transcription, DNA-templated [IDA]
- renal system development [ISO]
- rostrocaudal neural tube patterning [IMP]
- signal transduction involved in regulation of gene expression [IDA]
- spermatogenesis [IDA]
- stem cell differentiation [IMP]
- stem cell fate specification [IDA]
- transcription from RNA polymerase II promoter [IDA]
- vasculogenesis [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- beta-catenin binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- beta-catenin binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
ATP1A1
Atpa-1, BC010319
ATPase, Na+/K+ transporting, alpha 1 polypeptide
GO Process (24)
GO Function (13)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- cellular potassium ion homeostasis [ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to steroid hormone stimulus [ISO]
- cellular sodium ion homeostasis [ISO]
- dephosphorylation [IMP]
- membrane hyperpolarization [ISO]
- membrane repolarization [ISO]
- negative regulation of glucocorticoid biosynthetic process [IMP]
- negative regulation of heart contraction [IMP]
- positive regulation of heart contraction [IMP]
- positive regulation of striated muscle contraction [IMP]
- potassium ion import [ISO]
- potassium ion transmembrane transport [IMP]
- potassium ion transport [ISO]
- regulation of blood pressure [IGI]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of sodium ion transport [ISO]
- regulation of the force of heart contraction [IMP]
- response to drug [IMP]
- response to glycoside [IGI]
- sodium ion export from cell [ISO]
- sodium ion transmembrane transport [IMP, ISO]
- sodium ion transport [ISO]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ankyrin binding [ISO]
- chaperone binding [ISO]
- phosphatase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- sodium ion binding [ISO]
- sodium:potassium-exchanging ATPase activity [IDA, IMP, ISO]
- steroid hormone binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ankyrin binding [ISO]
- chaperone binding [ISO]
- phosphatase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- sodium ion binding [ISO]
- sodium:potassium-exchanging ATPase activity [IDA, IMP, ISO]
- steroid hormone binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- T-tubule [IDA, ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- caveola [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular vesicular exosome [ISO]
- intercalated disc [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- myelin sheath [IDA]
- neuronal postsynaptic density [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sodium:potassium-exchanging ATPase complex [ISO]
- vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.
Interleukin-22 (IL-22) belongs to the IL-10 cytokine family and is mainly produced by activated Th1 cells. Although IL-22 expression is reported to be elevated in many cancers, and increased IL-22 expression correlates with tumor progression and poor prognosis, little is known about the role of IL-22 in papillary thyroid cancer (PTC). We previously demonstrated that IL-22 promotes PTC cell migration ... [more]
Cell Commun Signal Dec. 10, 2018; 17(1);162 [Pubmed: 31823782]
Throughput
- High Throughput
Curated By
- BioGRID