GSK3B
Gene Ontology Biological Process
- ER overload response [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- axon guidance [TAS]
- canonical Wnt signaling pathway [IC, IDA]
- cellular response to interleukin-3 [ISS]
- circadian rhythm [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- epithelial to mesenchymal transition [IMP]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glycogen metabolic process [IDA]
- hippocampus development [IMP]
- innate immune response [TAS]
- intracellular signal transduction [IDA]
- negative regulation of NFAT protein import into nucleus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [TAS]
- negative regulation of glycogen (starch) synthase activity [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of protein binding [IDA]
- negative regulation of protein complex assembly [IMP]
- negative regulation of type B pancreatic cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISS]
- positive regulation of protein binding [ISS]
- positive regulation of protein catabolic process [IC]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein export from nucleus [IDA]
- protein phosphorylation [IDA]
- regulation of microtubule-based process [IMP]
- superior temporal gyrus development [IMP]
Gene Ontology Molecular Function- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
CABYR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.
To explore more possible roles for GSK3beta function, the yeast two-hybrid screening using GSK3beta as a bait protein was performed. In this study, we demonstrated that two variants of CABYR (281 and 379) interacted with GSK3beta in the yeast two-hybrid and GST pull down assay. Molecular characterization showed that CABYR variants formed a dimer with a proline-rich extensin-like domain, which ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GSK3B CABYR | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2910649 | |
| GSK3B CABYR | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID