TET1
Gene Ontology Biological Process
Gene Ontology Molecular Function
RELN
Gene Ontology Biological Process
- axon guidance [ISS]
- brain development [ISS]
- cell morphogenesis involved in differentiation [ISS]
- central nervous system development [ISS]
- cerebral cortex tangential migration [ISS]
- glial cell differentiation [ISS]
- hippocampus development [ISS]
- neuron migration [ISS]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of CREB transcription factor activity [ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- positive regulation of dendritic spine morphogenesis [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of long-term synaptic potentiation [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of protein kinase activity [ISS]
- positive regulation of protein tyrosine kinase activity [ISS]
- positive regulation of small GTPase mediated signal transduction [ISS]
- positive regulation of synapse maturation [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- reelin-mediated signaling pathway [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of behavior [ISS]
- regulation of synaptic transmission [ISS]
- response to pain [ISS]
- spinal cord patterning [ISS]
Gene Ontology Molecular Function
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.
The down regulation of glutamic acid decarboxylase67 (GAD1), reelin (RELN), and BDNF expression in brain of schizophrenia (SZ) and bipolar (BP) disorder patients is associated with overexpression of DNA methyltransferase1 (DNMT1) and ten-eleven translocase methylcytosine dioxygenase1 (TET1). DNMT1 and TET1 belong to families of enzymes that methylate and hydroxymethylate cytosines located proximal to and within cytosine phosphodiester guanine (CpG) islands ... [more]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID