Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.

Dong E, Ruzicka WB, Grayson DR, Guidotti A

The down regulation of glutamic acid decarboxylase67 (GAD1), reelin (RELN), and BDNF expression in brain of schizophrenia (SZ) and bipolar (BP) disorder patients is associated with overexpression of DNA methyltransferase1 (DNMT1) and ten-eleven translocase methylcytosine dioxygenase1 (TET1). DNMT1 and TET1 belong to families of enzymes that methylate and hydroxymethylate cytosines located proximal to and within cytosine phosphodiester guanine (CpG) islands ... [more]

Schizophr Res Sep. 01, 2015; 167(1-3);35-41 [Pubmed: 25476119]

Throughput

Low Throughput

Additional Notes

ChIP

Curated By

BioGRID

Interaction Summary

TET1

Gene Ontology Biological Process

Gene Ontology Molecular Function

iron ion binding [IDA]methylcytosine dioxygenase activity [IDA, IMP]structure-specific DNA binding [IDA]

Gene Ontology Cellular Component

GAD1

Gene Ontology Biological Process

Gene Ontology Molecular Function

glutamate decarboxylase activity [IDA]protein binding [IPI]

Gene Ontology Cellular Component

Co-localization

Publication

DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.

Throughput

Additional Notes

Curated By

iron ion binding [IDA]
methylcytosine dioxygenase activity [IDA, IMP]
structure-specific DNA binding [IDA]

glutamate decarboxylase activity [IDA]
protein binding [IPI]