1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, RP11-346D6.1
protein kinase, cGMP-dependent, type I
Homo sapiens


Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.


Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction.

Airhart N, Yang YF, Roberts CT, Silberbach M

Circulating natriuretic peptides such as atrial natriuretic peptide (ANP) counterbalance the effects of hypertension and inhibit cardiac hypertrophy by activating cGMP-dependent protein kinase (PKG). Natriuretic peptide binding to type I receptors (NPRA and NPRB) activates their intrinsic guanylyl cyclase activity, resulting in a rapid increase in cytosolic cGMP that subsequently activates PKG. Phosphorylation of the receptor by an unknown serine/threonine ... [more]

J. Biol. Chem. Oct. 03, 2003; 278(40);38693-8 [Pubmed: 12855709]


  • Low Throughput

Curated By

  • BioGRID