BAIT
PRKG1
1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, RP11-346D6.1
protein kinase, cGMP-dependent, type I
GO Process (5)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
NPR1
ANPRA, ANPa, GUC2A, GUCY2A, NPRA, RP11-354A16.3
natriuretic peptide receptor 1
GO Process (12)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [NAS]
- body fluid secretion [TAS]
- cGMP biosynthetic process [IDA]
- cell surface receptor signaling pathway [NAS]
- negative regulation of angiogenesis [TAS]
- negative regulation of cell growth [NAS]
- positive regulation of renal sodium excretion [TAS]
- positive regulation of urine volume [TAS]
- receptor guanylyl cyclase signaling pathway [IDA]
- regulation of blood pressure [NAS]
- regulation of vascular permeability [TAS]
- regulation of vasodilation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction.
Circulating natriuretic peptides such as atrial natriuretic peptide (ANP) counterbalance the effects of hypertension and inhibit cardiac hypertrophy by activating cGMP-dependent protein kinase (PKG). Natriuretic peptide binding to type I receptors (NPRA and NPRB) activates their intrinsic guanylyl cyclase activity, resulting in a rapid increase in cytosolic cGMP that subsequently activates PKG. Phosphorylation of the receptor by an unknown serine/threonine ... [more]
J. Biol. Chem. Oct. 03, 2003; 278(40);38693-8 [Pubmed: 12855709]
Throughput
- Low Throughput
Curated By
- BioGRID