YAP1
Gene Ontology Biological Process
- cell morphogenesis [IMP]
- cell proliferation [ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to gamma radiation [ISO]
- cellular response to retinoic acid [IDA]
- contact inhibition [ISO]
- embryonic heart tube morphogenesis [IGI]
- hippo signaling [IGI]
- keratinocyte differentiation [IGI, IMP]
- lateral mesoderm development [IGI]
- negative regulation of epithelial cell differentiation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IGI]
- negative regulation of nucleic acid-templated transcription [ISO]
- negative regulation of stem cell differentiation [IDA]
- notochord development [IGI]
- paraxial mesoderm development [IGI]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of organ growth [IDA]
- positive regulation of stem cell maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- regulation of canonical Wnt signaling pathway [IGI]
- regulation of cell proliferation [IGI]
- regulation of keratinocyte proliferation [IMP]
- regulation of metanephric nephron tubule epithelial cell differentiation [IGI]
- regulation of stem cell proliferation [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [IPI]
- somatic stem cell maintenance [IDA]
- transcription from RNA polymerase II promoter [IPI]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
ANXA11
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.
The inhibitory effect of large tumor suppressor kinase (LATS1/2) on the activity of the oncoprotein yes-associated protein (YAP) is crucial to maintain tissue homeostasis. Proteomic studies have identified several new regulators of this process. Recently, citron kinase (CIT) was listed as a potential binding candidate of Hippo-related components, suggesting a new connection between CIT and the Hippo pathway. Aside from ... [more]
Throughput
- High Throughput
Curated By
- BioGRID