BAIT
LATS2
4932411G09Rik, AV277261, AW228608
large tumor suppressor 2
GO Process (10)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA, ISO]
- cellular protein localization [IDA, IGI]
- hippo signaling [IGI, ISO]
- hormone-mediated signaling pathway [ISO]
- intracellular signal transduction [ISO]
- keratinocyte differentiation [IGI]
- negative regulation of canonical Wnt signaling pathway [IGI, ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of organ growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CIT
C030025P15Rik, CRIK, CRIK-SK, Cit-k
citron
GO Process (14)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- Golgi organization [ISO]
- cytokinesis [IMP, ISO]
- dendrite development [IMP]
- generation of neurons [IDA]
- metaphase/anaphase transition of mitotic cell cycle [IMP]
- mitotic nuclear division [IDA]
- mitotic sister chromatid segregation [IMP]
- negative regulation of dendrite morphogenesis [IDA]
- negative regulation of neuron differentiation [ISO]
- positive regulation of cytokinesis [ISO]
- protein phosphorylation [IDA]
- regulation of actin polymerization or depolymerization [ISO]
- spermatogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.
The inhibitory effect of large tumor suppressor kinase (LATS1/2) on the activity of the oncoprotein yes-associated protein (YAP) is crucial to maintain tissue homeostasis. Proteomic studies have identified several new regulators of this process. Recently, citron kinase (CIT) was listed as a potential binding candidate of Hippo-related components, suggesting a new connection between CIT and the Hippo pathway. Aside from ... [more]
J Mol Cell Biol Dec. 23, 2018; 11(11);1006-1017 [Pubmed: 30865227]
Throughput
- Low Throughput
Additional Notes
- Source of LATS2 not clear
Curated By
- BioGRID