BAIT
FMR1
FMRP, FRAXA, POF, POF1
fragile X mental retardation 1
GO Process (2)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TAF9B
DN-7, DN7, TAF9L, TAFII31L, TFIID-31, RP4-570L12.2
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IC]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of cell growth [IMP]
- protein stabilization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.
The prevalence of autism spectrum disorders (ASDs) is rapidly growing, yet its molecular basis is poorly understood. We used a systems approach in which ASD candidate genes were mapped onto the ubiquitous human protein complexes and the resulting complexes were characterized. The studies revealed the role of histone deacetylases (HDAC1/2) in regulating the expression of ASD orthologs in the embryonic ... [more]
Cell Syst Nov. 25, 2015; 1(5);361-374 [Pubmed: 26949739]
Throughput
- High Throughput
Additional Notes
- SAINT probability >80%
Curated By
- BioGRID