DYRK1A
Gene Ontology Biological Process
- circadian rhythm [ISS]
- mitotic cell cycle [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISS]
- nervous system development [TAS]
- peptidyl-threonine phosphorylation [ISS]
- peptidyl-tyrosine phosphorylation [IDA, ISS]
- positive regulation of protein deacetylation [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LZTS3
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.
The prevalence of autism spectrum disorders (ASDs) is rapidly growing, yet its molecular basis is poorly understood. We used a systems approach in which ASD candidate genes were mapped onto the ubiquitous human protein complexes and the resulting complexes were characterized. The studies revealed the role of histone deacetylases (HDAC1/2) in regulating the expression of ASD orthologs in the embryonic ... [more]
Throughput
- High Throughput
Additional Notes
- SAINT probability >80%
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LZTS3 DYRK1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9996 | BioGRID | 3273761 | |
| LZTS3 DYRK1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9999 | BioGRID | 3067544 | |
| DYRK1A LZTS3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2633268 |
Curated By
- BioGRID