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BAIT

GRIN2B

GluN2B, MRD6, NMDAR2B, NR2B, hNR3

glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Alzheimer's Disease Project

GO Process (8)

GO Function (5)

GO Component (7)

Gene Ontology Biological Process

glutamate receptor signaling pathway [TAS]

ion transmembrane transport [IBA]

ionotropic glutamate receptor signaling pathway [IBA]

learning or memory [TAS]

response to ethanol [IDA]

synaptic transmission [TAS]

synaptic transmission, glutamatergic [IBA]

transport [TAS]

Gene Ontology Molecular Function

N-methyl-D-aspartate selective glutamate receptor activity [IBA]
extracellular-glutamate-gated ion channel activity [IBA]
glycine binding [IDA]
protein binding [IPI]
zinc ion binding [ISS]

Gene Ontology Cellular Component

N-methyl-D-aspartate selective glutamate receptor complex [IDA]

cell surface [ISS]

integral component of plasma membrane [TAS]

neuron projection [ISS]

plasma membrane [TAS]

postsynaptic membrane [IBA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB HPRD

Homo sapiens

PREY

AP1M1

AP47, CLAPM2, CLTNM, MU-1A

adaptor-related protein complex 1, mu 1 subunit

GO Process (7)

GO Function (1)

GO Component (7)

Gene Ontology Biological Process

antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]

endosome to melanosome transport [IMP]

melanosome organization [IMP]

membrane organization [TAS]

post-Golgi vesicle-mediated transport [TAS]

regulation of defense response to virus by virus [TAS]

viral process [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

Golgi membrane [TAS]

cytoplasmic vesicle membrane [TAS]

extracellular vesicular exosome [IDA]

lysosomal membrane [TAS]

trans-Golgi network membrane [TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Subunit-specific regulation of NMDA receptor endocytosis.

Lavezzari G, McCallum J, Dewey CM, Roche KW

At excitatory synapses, both NMDA and AMPA receptors are localized to the postsynaptic density (PSD). However, unlike AMPA receptors, synaptic NMDA receptors are stable components of the PSD. Even so, surface-expressed NMDA receptors undergo endocytosis, which is more robust early in development and declines during synaptic development. We investigated the subunit-specific contributions to NMDA receptor endocytosis, specifically defining the endocytic ... [more]

J Neurosci Jul. 14, 2004; 24(28);6383-91 [Pubmed: 15254094]

Throughput

Low Throughput

Curated By

BioGRID